Ontology highlight
ABSTRACT:
SUBMITTER: Perrin GQ
PROVIDER: S-EPMC5142511 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Perrin George Q GQ Zolotukhin Irene I Sherman Alexandra A Biswas Moanaro M de Jong Ype P YP Terhorst Cox C Davidoff Andrew M AM Herzog Roland W RW
Molecular therapy. Methods & clinical development 20161207
The tolerogenic hepatic microenvironment impedes clearance of viral infections but is an advantage in viral vector gene transfer, which often results in immune tolerance induction to transgene products. Although the underlying tolerance mechanism has been extensively studied, our understanding of antigen presentation to transgene product-specific CD4<sup>+</sup> T cells remains limited. To address this, we administered hepatotropic adeno-associated virus (AAV8) vector expressing cytoplasmic oval ...[more]