Ontology highlight
ABSTRACT:
SUBMITTER: Kurasawa Y
PROVIDER: S-EPMC514520 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Kurasawa Yasuhiro Y Earnshaw William C WC Mochizuki Yuko Y Dohmae Naoshi N Todokoro Kazuo K
The EMBO journal 20040805 16
A number of proteins accumulate in the anaphase spindle midzone, but the interaction and precise role of these proteins in midzone organization remain obscure. Here, we found that the microtubule-bundling protein PRC1 bound separately to the three motor proteins, KIF4, MKLP1 and CENP-E, but not to the chromosomal passenger proteins. In KIF4-deficient cells, the central spindle was disorganized, and all midzone-associated proteins including PRC1 failed to concentrate at the midline, instead being ...[more]