Ontology highlight
ABSTRACT:
SUBMITTER: Bowen DG
PROVIDER: S-EPMC514586 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Bowen David G DG Zen Monica M Holz Lauren L Davis Thomas T McCaughan Geoffrey W GW Bertolino Patrick P
The Journal of clinical investigation 20040901 5
Hepatic immunobiology is paradoxical: although the liver possesses unusual tolerogenic properties, it is also the site of effective immune responses against multiple pathogens and subject to immune-mediated pathology. The mechanisms underlying this dichotomy remain unclear. Following previous work demonstrating that the liver may act as a site of primary T cell activation, we demonstrate here that the balance between immunity and tolerance in this organ is established by competition for primary ...[more]