Unknown

Dataset Information

0

Secondary Metabolites and Biological Activities of Talaromyces sp. LGT-2, an Endophytic Fungus from Tripterygium Wilfordii.


ABSTRACT: In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing previous literature data. This is the first report of the isolation of alkaloids (1-9) from Talaromyces genus. In the next step, all compounds were screened for their anti-monoamine oxidase, anti-acetylcholinesterase, antibacterial and antitumor activities. Compound 11 showed moderate anti-monoamine oxidase activity with IC50 value of 61 ?M; compounds 3, 4, 8 showed weaker anti-acetylcholinesterase activity; compounds 1, 3, 4, 7, 8, 9 showed moderate antibacterial activities; compounds 7, 8, 9 showed cytotoxicity against B16 cancer cell line with inhibitory rate of 86%, 82%, 78%, respectively, at the concentration of 500 ?g/mL.

SUBMITTER: Zhao QH 

PROVIDER: S-EPMC5149032 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

altmetric image

Publications

Secondary Metabolites and Biological Activities of <i>Talaromyces sp.</i> LGT-2<i>,</i> an Endophytic Fungus from <i>Tripterygium Wilfordii</i>.

Zhao Qiu-Hong QH   Yang Zhong-Duo ZD   Shu Zong-Mei ZM   Wang Yong-Gang YG   Wang Ming-Gang MG  

Iranian journal of pharmaceutical research : IJPR 20160101 3


In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from <i>Talaromyces sp.</i> LGT-2, an endophytic fungus from <i>Tripterygium wilfordi</i>. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing previous literature data. This is the first report of the isolation of alkaloids (1-9) from <i>Talaromyces</i> genus. In the next step, all compounds were screened for the  ...[more]

Similar Datasets

| S-EPMC8465095 | biostudies-literature
| S-EPMC7667569 | biostudies-literature
| S-EPMC5913051 | biostudies-literature
| S-EPMC6271730 | biostudies-literature
| S-EPMC10708468 | biostudies-literature
| S-EPMC6597039 | biostudies-literature
| S-EPMC8885587 | biostudies-literature
| S-EPMC7462088 | biostudies-literature
| S-EPMC10591187 | biostudies-literature
| S-EPMC9702824 | biostudies-literature