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Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.

ABSTRACT: Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1-6, together with five known compounds, 7-11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds, and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.

SUBMITTER: Tran TD

PROVIDER: S-EPMC7462088 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.

Tran Trong D TD Wilson Brice A P BAP Henrich Curtis J CJ Staudt Louis M LM Krumpe Lauren R H LRH Smith Emily A EA King Jarrod J Wendt Karen L KL Stchigel Alberto M AM Miller Andrew N AN Cichewicz Robert H RH O'Keefe Barry R BR Gustafson Kirk R KR

Journal of natural products 20190102 1

Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1-6, together with five known compounds, 7-11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structu ...[more]

PMID: 30600998

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