Ontology highlight
ABSTRACT:
SUBMITTER: Egan MF
PROVIDER: S-EPMC515104 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Egan Michael F MF Straub Richard E RE Goldberg Terry E TE Yakub Imtiaz I Callicott Joseph H JH Hariri Ahmad R AR Mattay Venkata S VS Bertolino Alessandro A Hyde Thomas M TM Shannon-Weickert Cynthia C Akil Mayada M Crook Jeremy J Vakkalanka Radha Krishna RK Balkissoon Rishi R Gibbs Richard A RA Kleinman Joel E JE Weinberger Daniel R DR
Proceedings of the National Academy of Sciences of the United States of America 20040813 34
GRM3, a metabotropic glutamate receptor-modulating synaptic glutamate, is a promising schizophrenia candidate gene. In a family-based association study, a common GRM3 haplotype was strongly associated with schizophrenia (P = 0.0001). Within this haplotype, the A allele of single-nucleotide polymorphism (SNP) 4 (hCV11245618) in intron 2 was slightly overtransmitted to probands (P = 0.02). We studied the effects of this SNP on neurobiological traits related to risk for schizophrenia and glutamate ...[more]