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1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis.

ABSTRACT: A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to C_sp³-centered alkyl radical coupling partners. The reported method is characterized by its extremely mild reaction conditions, enabling access to underexplored cores.

SUBMITTER: Gutierrez-Bonet A

PROVIDER: S-EPMC5152669 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis.

Gutiérrez-Bonet Álvaro Á Tellis John C JC Matsui Jennifer K JK Vara Brandon A BA Molander Gary A GA

ACS catalysis 20161027 12

A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to C<sub>sp</sub><sup>3</sup>-centered alkyl radical coupling partners. The reported method is characterized by its extremely mild reaction conditions, enabling access to underexplored cores. ...[more]

PMID: 27990318

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