Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC5155572 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Liu Qi Q Zhang Cheng C Ding Xianting X Deng Hui H Zhang Daming D Cui Wei W Xu Hongwei H Wang Yingwei Y Xu Wanhai W Lv Lei L Lv Lei L Zhang Hongyu H He Yinghua Y Wu Qiong Q Szyf Moshe M Ho Chih-Ming CM Zhu Jingde J
Scientific reports 20150619
Therapeutic outcomes of combination chemotherapy have not significantly advanced during the past decades. This has been attributed to the formidable challenges of optimizing drug combinations. Testing a matrix of all possible combinations of doses and agents in a single cell line is unfeasible due to the virtually infinite number of possibilities. We utilized the Feedback System Control (FSC) platform, a phenotype oriented approach to test 100 options among 15,625 possible combinations in four r ...[more]