Ontology highlight
ABSTRACT:
SUBMITTER: Salifou K
PROVIDER: S-EPMC5157185 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Salifou Kader K Ray Swagat S Verrier Laure L Aguirrebengoa Marion M Trouche Didier D Panov Konstantin I KI Vandromme Marie M
Nature communications 20160105
The interplay between methylation and demethylation of histone lysine residues is an essential component of gene expression regulation and there is considerable interest in elucidating the roles of proteins involved. Here we report that histone demethylase KDM4A/JMJD2A, which is involved in the regulation of cell proliferation and is overexpressed in some cancers, interacts with RNA Polymerase I, associates with active ribosomal RNA genes and is required for serum-induced activation of rDNA tran ...[more]