The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
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ABSTRACT:
SUBMITTER: Cascella B
PROVIDER: S-EPMC5511625 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
The small molecule JIB-04 disrupts O<sub>2</sub> binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Cascella Barbara B Lee Soon Goo SG Singh Sukrit S Jez Joseph M JM Mirica Liviu M LM
Chemical communications (Cambridge, England) 20170201 13
JIB-04, a specific inhibitor of the O<sub>2</sub>-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O<sub>2</sub> in KDM4A/JMJD2A through a continuous O<sub>2</sub>-consumption assay, X-ray crystal structure data, and molecular docking. ...[more]
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