Ontology highlight
ABSTRACT:
SUBMITTER: Katigbak A
PROVIDER: S-EPMC5159885 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Katigbak Alexandra A Cencic Regina R Robert Francis F Sénécha Patrick P Scuoppo Claudio C Pelletier Jerry J
Scientific reports 20161216
An enormous amount of tumor sequencing data has been generated through large scale sequencing efforts. The functional consequences of the majority of mutations identified by such projects remain an open, unexplored question. This problem is particularly complicated in the case of rare mutations where frequency of occurrence alone or prediction of functional consequences are insufficient to distinguish driver from passenger or bystander mutations. We combine genome editing technology with a power ...[more]