Ontology highlight
ABSTRACT:
SUBMITTER: Lahtela J
PROVIDER: S-EPMC3594263 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Lahtela Jenni J Corson Laura B LB Hemmes Annabrita A Brauer Matthew J MJ Koopal Sonja S Lee James J Hunsaker Thomas L TL Jackson Peter K PK Verschuren Emmy W EW
Cell cycle (Georgetown, Tex.) 20130116 4
Activation of a cellular senescence program is a common response to prolonged oncogene activation or tumor suppressor loss, providing a physiological mechanism for tumor suppression in premalignant cells. The link between senescence and tumor suppression supports the hypothesis that a loss-of-function screen measuring bona fide senescence marker activation should identify candidate tumor suppressors. Using a high-content siRNA screening assay for cell morphology and proliferation measures, we id ...[more]