Ontology highlight
ABSTRACT:
SUBMITTER: Dambuza IM
PROVIDER: S-EPMC5171238 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Dambuza Ivy M IM Keeton Roanne R Hsu Nai-Jen NJ Allie Nasiema N Quesniaux Valérie F J VF Ryffel Bernhard B Jacobs Muazzam M
Scientific reports 20161220
The pleiotropic activities of TNF are mediated by two structurally related but functionally distinct type I transmembrane receptors, p55TNFR and p75TNFR expressed in most cell types, that can be cleaved and act as TNF scavengers. Here, we investigated the effect of persistent p55TNFR cell surface expression during aerosol inhalation challenge with virulent M. tuberculosis H37Rv. We demonstrated that persistency of p55TNFR in macrophage cultures increased the synthesis of soluble TNF, p75TNFR and ...[more]