Ontology highlight
ABSTRACT:
SUBMITTER: Yamagata N
PROVIDER: S-EPMC5172549 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
PLoS biology 20161220 12
Massive activation of dopamine neurons is critical for natural reward and drug abuse. In contrast, the significance of their spontaneous activity remains elusive. In Drosophila melanogaster, depolarization of the protocerebral anterior medial (PAM) cluster dopamine neurons en masse signals reward to the mushroom body (MB) and drives appetitive memory. Focusing on the functional heterogeneity of PAM cluster neurons, we identified that a single class of PAM neurons, PAM-γ3, mediates sugar reward b ...[more]