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Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation.

ABSTRACT: A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C-H activation of benzylic C-H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.

SUBMITTER: Yuan G

PROVIDER: S-EPMC5179041 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation.

Yuan Gengyang G Wang Feng F Stephenson Nickeisha A NA Wang Lu L Rotstein Benjamin H BH Vasdev Neil N Tang Pingping P Liang Steven H SH

Chemical communications (Cambridge, England) 20161201 1

A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C-H activation of benzylic C-H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes. ...[more]

PMID: 27917423

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