Ontology highlight
ABSTRACT:
SUBMITTER: Cooney JD
PROVIDER: S-EPMC5179339 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Cooney Jeffrey D JD Aguiar Ricardo C T RC
Blood 20161018 25
Phosphodiesterase 4 (PDE4) inhibition restores the suppressive effects of 3',5'-cyclic adenosine monophosphate in lymphocytes. In this concise review, we detail how PDE4 inhibition downmodulates the B-cell receptor (BCR)-related kinases spleen tyrosine kinase and phosphatidylinositol 3-kinase and inhibits vascular endothelial growth factor A secretion by tumor cells, inducing cancer cell apoptosis and blocking angiogenesis in the microenvironment. We describe the successful clinical repurposing ...[more]