Ontology highlight
ABSTRACT:
SUBMITTER: Kwak JH
PROVIDER: S-EPMC5190041 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Kwak Ji-Hye JH Lee Na-Hee NH Lee Hwa-Yong HY Hong In-Sun IS Nam Jeong-Seok JS
Oncotarget 20160701 28
Breast cancer stem cells (BCSCs) have been shown to contribute to tumor growth, metastasis, and recurrence. They are also markedly resistant to conventional cancer treatments, such as chemotherapy and radiation. Recent studies have suggested that hypoxia is one of the prominent micro-environmental factors that increase the self-renewal ability of BCSCs, partially by enhancing CSC phenotypes. Thus, the identification and development of new therapeutic approaches based on targeting the hypoxia-dep ...[more]