Ontology highlight
ABSTRACT:
SUBMITTER: Clemente N
PROVIDER: S-EPMC5206443 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Clemente Nausicaa N Raineri Davide D Cappellano Giuseppe G Boggio Elena E Favero Francesco F Soluri Maria Felicia MF Dianzani Chiara C Comi Cristoforo C Dianzani Umberto U Chiocchetti Annalisa A
Journal of immunology research 20161220
Osteopontin (OPN) regulates the immune response at multiple levels. Physiologically, it regulates the host response to infections by driving T helper (Th) polarization and acting on both innate and adaptive immunity; pathologically, it contributes to the development of immune-mediated and inflammatory diseases. In some cases, the mechanisms of these effects have been described, but many aspects of the OPN function remain elusive. This is in part ascribable to the fact that OPN is a complex molec ...[more]