Ontology highlight
ABSTRACT:
SUBMITTER: He B
PROVIDER: S-EPMC5206500 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
He Baokun B Hoang Thomas K TK Wang Ting T Ferris Michael M Taylor Christopher M CM Tian Xiangjun X Luo Meng M Tran Dat Q DQ Zhou Jain J Tatevian Nina N Luo Fayong F Molina Jose G JG Blackburn Michael R MR Gomez Thomas H TH Roos Stefan S Rhoads J Marc JM Liu Yuying Y
The Journal of experimental medicine 20161219 1
Regulatory T (T reg) cell deficiency causes lethal, CD4<sup>+</sup> T cell-driven autoimmune diseases. Stem cell transplantation is used to treat these diseases, but this procedure is limited by the availability of a suitable donor. The intestinal microbiota drives host immune homeostasis by regulating the differentiation and expansion of T reg, Th1, and Th2 cells. It is currently unclear if T reg cell deficiency-mediated autoimmune disorders can be treated by targeting the enteric microbiota. H ...[more]