Association of timing of menarche with depressive symptoms and depression in adolescence: Mendelian randomisation study.
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ABSTRACT:
SUBMITTER: Sequeira ME
PROVIDER: S-EPMC5209630 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Association of timing of menarche with depressive symptoms and depression in adolescence: Mendelian randomisation study.
Sequeira Maija-Eliina ME Lewis Sarah J SJ Bonilla Carolina C Smith George Davey GD Joinson Carol C
The British journal of psychiatry : the journal of mental science 20160804 1
<h4>Background</h4>Observational studies report associations between early menarche and higher levels of depressive symptoms and depression. However, no studies have investigated whether this association is causal.<h4>Aims</h4>To determine whether earlier menarche is a causal risk factor for depressive symptoms and depression in adolescence.<h4>Method</h4>The associations between a genetic score for age at menarche and depressive symptoms at 14, 17 and 19 years, and depression at 18 years, were ...[more]
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