Ontology highlight
ABSTRACT:
SUBMITTER: Hong F
PROVIDER: S-EPMC5215799 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Hong Feng F Mohammad Rachidi Saleh S Lundgren Debbie D Han David D Huang Xiu X Zhao Hongyu H Kimura Yayoi Y Hirano Hisashi H Ohara Osamu O Udono Heichiiro H Meng Songdong S Liu Bei B Li Zihai Z
PloS one 20170105 1
Up to 10% of cytosolic proteins are dependent on the mammalian heat shock protein 90 (HSP90) for folding. However, the interactors of its endoplasmic reticulum (ER) paralogue (gp96, Grp94 and HSP90b1) has not been systematically identified. By combining genetic and biochemical approaches, we have comprehensively mapped the interactome of gp96 in macrophages and B cells. A total of 511 proteins were reduced in gp96 knockdown cells, compared to levels observed in wild type cells. By immunoprecipit ...[more]