Ontology highlight
ABSTRACT:
SUBMITTER: Soethoudt M
PROVIDER: S-EPMC5216056 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nature communications 20170103
The cannabinoid CB<sub>2</sub> receptor (CB<sub>2</sub>R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB<sub>2</sub>R, their selectivity, molecular mode of action and pharmacokinetic properties have been poorly characterized. Here we report the most extensive characterization of the molecular pharmacology of the most widely used CB<sub>2</sub>R ligands to date. In ...[more]