Ontology highlight
ABSTRACT:
SUBMITTER: Xie S
PROVIDER: S-EPMC5221585 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20160803 22
During development, coordinated cell shape changes alter tissue shape. In the Drosophila ventral furrow and other epithelia, apical constriction of hundreds of epithelial cells folds the tissue. Genes in the G<sub>α12/13</sub> pathway coordinate collective apical constriction, but the mechanism of coordination is poorly understood. Coupling live-cell imaging with a computational approach to identify contractile events, we discovered that differences in constriction behavior are biased by initial ...[more]