Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC5221611 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Chen Jing J Zheng Qi Q Hammers Christoph M CM Ellebrecht Christoph T CT Mukherjee Eric M EM Tang Hsin-Yao HY Lin Chenyan C Yuan Huijie H Pan Meng M Langenhan Jana J Komorowski Lars L Siegel Don L DL Payne Aimee S AS Stanley John R JR
Cell reports 20170101 1
In autoantibody-mediated diseases such as pemphigus, serum antibodies lead to disease. Genetic analysis of B cells has allowed characterization of antibody repertoires in such diseases but would be complemented by proteomic analysis of serum autoantibodies. Here, we show using proteomic analysis that the serum autoantibody repertoire in pemphigus is much more polyclonal than that found by genetic studies of B cells. In addition, many B cells encode pemphigus autoantibodies that are not secreted ...[more]