Ontology highlight
ABSTRACT:
SUBMITTER: Wolner BS
PROVIDER: S-EPMC85653 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20000501 10
Sequence blocks within the core region were swapped among RNA polymerase II promoters to explore effects on transcription in vitro. The pair of blocks flanking TATA strongly influenced general transcription, with an additional effect on promoter activation. These flanking elements induced a change in the ratio of activated to basal transcription, whereas swapping TATA and initiator sequences only altered general transcription levels. Swapping the flanking blocks influenced binding by general tra ...[more]