Ontology highlight
ABSTRACT:
SUBMITTER: Serezani APM
PROVIDER: S-EPMC5222746 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Serezani Ana P M APM Bozdogan Gunseli G Sehra Sarita S Walsh Daniel D Krishnamurthy Purna P Sierra Potchanant Elizabeth A EA Nalepa Grzegorz G Goenka Shreevrat S Turner Matthew J MJ Spandau Dan F DF Kaplan Mark H MH
The Journal of allergy and clinical immunology 20160820 1
<h4>Background</h4>Atopic dermatitis (AD) is characterized by intense pruritis and is a common childhood inflammatory disease. Many factors are known to affect AD development, including the pleiotropic cytokine IL-4. Yet little is known regarding the direct effects of IL-4 on keratinocyte function.<h4>Objective and methods</h4>In this report RNA sequencing and functional assays were used to define the effect of the allergic environment on primary keratinocyte function and wound repair in mice.<h ...[more]