Ontology highlight
ABSTRACT:
SUBMITTER: Kadlecova Z
PROVIDER: S-EPMC5223608 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Kadlecova Zuzana Z Spielman Stephanie J SJ Loerke Dinah D Mohanakrishnan Aparna A Reed Dana Kim DK Schmid Sandra L SL
The Journal of cell biology 20161221 1
The critical initiation phase of clathrin-mediated endocytosis (CME) determines where and when endocytosis occurs. Heterotetrameric adaptor protein 2 (AP2) complexes, which initiate clathrin-coated pit (CCP) assembly, are activated by conformational changes in response to phosphatidylinositol-4,5-bisphosphate (PIP2) and cargo binding at multiple sites. However, the functional hierarchy of interactions and how these conformational changes relate to distinct steps in CCP formation in living cells ...[more]