Ontology highlight
ABSTRACT:
SUBMITTER: Gulbranson DR
PROVIDER: S-EPMC6702059 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Developmental cell 20190725 4
Multimeric adaptors are broadly involved in vesicle-mediated membrane trafficking. AP2 adaptor, in particular, plays a central role in clathrin-mediated endocytosis (CME) by recruiting cargo and clathrin to endocytic sites. It is generally thought that trafficking adaptors such as AP2 adaptor assemble spontaneously. In this work, however, we discovered that AP2 adaptor assembly is an ordered process controlled by alpha and gamma adaptin binding protein (AAGAB), an uncharacterized factor identifi ...[more]