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Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA.

ABSTRACT: Here we described the preparation and characterization by atomic force microscopy of dumbbell-shaped conjugates between 450 bp double-stranded DNA polymer, poly(dG)-poly(dC), and 5 nm gold nanoparticles (GNPs). We have demonstrated that the size of the nanoparticles in the conjugates can be increased in a controlled fashion. Application of the conjugates for measuring the electrical conductivity of DNA is discussed.

SUBMITTER: Eidelshtein G

PROVIDER: S-EPMC5224630 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA.

Eidelshtein Gennady G Fattal Moran M Avishai Gavriel G Kempinski Benjamin B Giannini Clelia C Kotlyar Alexander A

Nanomaterials (Basel, Switzerland) 20160908 9

Here we described the preparation and characterization by atomic force microscopy of dumbbell-shaped conjugates between 450 bp double-stranded DNA polymer, poly(dG)-poly(dC), and 5 nm gold nanoparticles (GNPs). We have demonstrated that the size of the nanoparticles in the conjugates can be increased in a controlled fashion. Application of the conjugates for measuring the electrical conductivity of DNA is discussed. ...[more]

PMID: 28335294

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