Ontology highlight
ABSTRACT:
SUBMITTER: Knapp DJ
PROVIDER: S-EPMC5233451 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Knapp David J H F DJ Hammond Colin A CA Miller Paul H PH Rabu Gabrielle M GM Beer Philip A PA Ricicova Marketa M Lecault Véronique V Da Costa Daniel D VanInsberghe Michael M Cheung Alice M AM Pellacani Davide D Piret James J Hansen Carl C Eaves Connie J CJ
Stem cell reports 20170101 1
The role of growth factors (GFs) in controlling the biology of human hematopoietic stem cells (HSCs) remains limited by a lack of information concerning the individual and combined effects of GFs directly on the survival, Mitogenesis, and regenerative activity of highly purified human HSCs. We show that the initial input HSC activity of such a purified starting population of human cord blood cells can be fully maintained over a 21-day period in serum-free medium containing five GFs alone. HSC su ...[more]