Ontology highlight
ABSTRACT:
SUBMITTER: Bungartz G
PROVIDER: S-EPMC3286206 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Bungartz Gerd G Land Hannah H Scadden David T DT Emerson Stephen G SG
Blood 20111109 6
HSC function depends on the tight control of proliferation and the balance between self-renewal and differentiation. Here, we report that the trimeric transcription factor NF-Y is critical for the survival of cycling, but not quiescent HSCs. With the use of a conditional knockout mouse model, we demonstrate that NF-Ya deletion creates an accumulation of HSCs in G(2)/M and prompts apoptosis, causing hematopoietic failure and death of the animal. These defects are accompanied by the dysregulation ...[more]