Ontology highlight
ABSTRACT:
SUBMITTER: O'Kane GM
PROVIDER: S-EPMC5233870 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Translational lung cancer research 20161201 6
Brain metastases occur in approximately half of patients with non-small cell lung cancer (NSCLC) and are associated with a poor prognosis and an inferior quality of life. Historically systemic therapy has had a limited role in CNS disease with a reliance placed on local treatments. The emergence of targeted therapies and immune checkpoint inhibitors (ICIs) in recent years has dramatically changed the treatment landscape of NSCLC. Programmed cell death-1 (PD-1) inhibitors have demonstrated effica ...[more]