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Selective transition-metal-free vicinal cis-dihydroxylation of saturated hydrocarbons.

ABSTRACT: A transition-metal-free cis-dihydroxylation of saturated hydrocarbons under ambient reaction conditions has been developed. The described approach allows a direct and selective synthesis of vicinal diols. The new reaction thereby proceeds via radical iodination and a sequence of oxidation steps. A broad scope of one-pot dual C(sp³)-H bond functionalization for the selective synthesis of vicinal syn-diols was demonstrated.

SUBMITTER: Bering L

PROVIDER: S-EPMC5298187 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Selective transition-metal-free vicinal cis-dihydroxylation of saturated hydrocarbons.

Bering Luis L Antonchick Andrey P AP

Chemical science 20160822 1

A transition-metal-free cis-dihydroxylation of saturated hydrocarbons under ambient reaction conditions has been developed. The described approach allows a direct and selective synthesis of vicinal diols. The new reaction thereby proceeds via radical iodination and a sequence of oxidation steps. A broad scope of one-pot dual C(sp3)-H bond functionalization for the selective synthesis of vicinal syn-diols was demonstrated. ...[more]

PMID: 28451192

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