Ontology highlight
ABSTRACT:
SUBMITTER: Lennon CW
PROVIDER: S-EPMC5238726 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Lennon Christopher W CW Stanger Matthew M Belfort Marlene M
Genes & development 20161228 24
Inteins (or protein introns) autocatalytically excise themselves through protein splicing. We challenge the long-considered notion that inteins are merely molecular parasites and posit that some inteins evolved to regulate host protein function. Here we show substrate-induced and DNA damage-induced splicing, in which an archaeal recombinase RadA intein splices dramatically faster and more accurately when provided with ssDNA. This unprecedented example of intein splicing stimulation by the substr ...[more]