CTRC gene polymorphism (p.G60=; c.180 C?>?T) in acute pancreatitis.

ABSTRACT: The aim of the study was to determine the relationship between the presence of p.G60?=?polymorphism (c.180C?>?T; rs497078) CTRC and the incidence together with the clinical course of acute pancreatitis (AP).Two hundred ninety-nine people suffering from AP and 417 healthy volunteers were subjected to the study. DNA was isolated from blood samples.CTRC p.G60?=?polymorphism (c.180C?>?T) occurred more frequently in the AP group (p?=?0.015). The CT and TT genotype was found in 27.8% of the AP patients and in 19.9% of the healthy subjects (p?=?0.017). No significant correlation was found between having the CT and TT genotype and the severity of the AP clinical course. In 6 patients (2%) with the CT genotype, a SPINK1 gene mutation was found, while in the control group it was found in 3 patients (0.7%), (p?>?0.05). All patients with the present SPINK1 mutation with the CT genotype had a moderate or a severe course of the disease (p?=?0.0007).CTRC polymorphism Hetero p.G60=; c.180C?>?T increases the risk of an AP occurrence and together with the SPINK 1 mutation, may be responsible for a more severe course of the disease.

SUBMITTER: Koziel D 

PROVIDER: S-EPMC5240263 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature