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Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients.

ABSTRACT:

Purpose

To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis.

Material and methods

Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS - 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated.

Results

We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis.

Conclusion

In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism.

SUBMITTER: Padureanu V

PROVIDER: S-EPMC4709709 | biostudies-literature | 2014 Oct-Dec

REPOSITORIES: biostudies-literature

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Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients.

Pădureanu V V StreaȚă Ioana I Ioana M M Șurlin V V Georgescu E F EF Mărginean Cristina C Săftoiu A A

Current health sciences journal 20141001 4

<h4>Purpose</h4>To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis.<h4>Material and methods</h4>Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS - 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism wi ...[more]

PMID: 26793321

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