Endogenous lysophosphatidic acid (LPA₁ ) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts.

ABSTRACT:

Background and purpose

Human lung fibroblasts (HLF) express high levels of the LPA₁ receptor, a GPCR that responds to the endogenous lipid mediator, lysophosphatidic acid (LPA). Several molecular species or analogues of LPA exist and have been detected in biological fluids such as serum and plasma. The most widely expressed of the LPA receptor family is the LPA₁ receptor, which predominantly couples to G_q/11 , G_i/o and G_12/13 proteins. This promiscuity of coupling raises the possibility that some of the LPA analogues may bias the LPA₁ receptor towards one signalling pathway over another.

Experimental approach

Here, we have explored the signalling profiles of a range of LPA analogues in HLF that endogenously ex

SUBMITTER: Sattikar A 

PROVIDER: S-EPMC5241385 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature