Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC5245983 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Zhao Xin X Tian Xin X Kajigaya Sachiko S Cantilena Caroline R CR Strickland Stephen S Savani Bipin N BN Mohan Sanjay S Feng Xingmin X Keyvanfar Keyvan K Dunavin Neil N Townsley Danielle M DM Dumitriu Bogdan B Battiwalla Minoo M Rezvani Katayoun K Young Neal S NS Barrett A John AJ Ito Sawa S
British journal of haematology 20160719 3
Although recent observations implicate the importance of telomerase activity in acute myeloid leukaemia (AML), the roles of epigenetic regulations of the TERT gene in leukaemogenesis, drug resistance and clinical prognosis in AML are not fully understood. We developed a quantitative pyrosequencing-based methylation assay covering the TERT proximal promoter and a partial exon 1 (TERTpro/Ex1) region and tested both cell lines and primary leukaemia cells derived from AML and AML with preceding myel ...[more]