Ontology highlight
ABSTRACT:
SUBMITTER: Binley JM
PROVIDER: S-EPMC524984 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Binley James M JM Wrin Terri T Korber Bette B Zwick Michael B MB Wang Meng M Chappey Colombe C Stiegler Gabriela G Kunert Renate R Zolla-Pazner Susan S Katinger Hermann H Petropoulos Christos J CJ Burton Dennis R DR
Journal of virology 20041201 23
Broadly neutralizing monoclonal antibodies (MAbs) are potentially important tools in human immunodeficiency virus type 1 (HIV-1) vaccine design. A few rare MAbs have been intensively studied, but we still have a limited appreciation of their neutralization breadth. Using a pseudovirus assay, we evaluated MAbs from clade B-infected donors and a clade B HIV(+) plasma against 93 viruses from diverse backgrounds. Anti-gp120 MAbs exhibited greater activity against clade B than non-B viruses, whereas ...[more]