Ontology highlight
ABSTRACT:
SUBMITTER: Tebo AG
PROVIDER: S-EPMC5250511 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Metallomics : integrated biometal science 20151027 12
Members of the ArsR/SmtB family of transcriptional repressors, such as CadC, regulate the intracellular levels of heavy metals like Cd(II), Hg(II), and Pb(II). These metal sensing proteins bind their target metals with high specificity and affinity, however, a lack of structural information about these proteins makes defining the coordination sphere of the target metal difficult. Lingering questions as to the identity of Cd(II) coordination in CadC are addressed via protein design techniques. Tw ...[more]