Ontology highlight
ABSTRACT:
SUBMITTER: G-Dayanandan N
PROVIDER: S-EPMC5253071 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
G-Dayanandan Narendran N Scocchera Eric W EW Keshipeddy Santosh S Jones Heather F HF Anderson Amy C AC Wright Dennis L DL
Organic letters 20161213 1
To develop next generation antifolates for the treatment of trimethoprim-resistant bacteria, synthetic methods were needed to prepare a diverse array of 3-aryl-propynes with various substitutions at the propargyl position. A direct route was sought whereby nucleophilic addition of acetylene to aryl carboxaldehydes would be followed by reduction or substitution of the resulting propargyl alcohol. The direct reduction, methylation, and dimethylation of these readily available alcohols provide effi ...[more]