Easy Access to Phosphine-Borane Building Blocks.

ABSTRACT: In this paper, we highlight the synthesis of a variety of primary phosphine-boranes (RPH₂ ?BH₃ ) from the corresponding dichlorophosphines, simply by using Li[BH₄ ] as reductant and provider of the BH₃ protecting group. The method offers facile access not only to alkyl- and arylphosphine-boranes, but also to aminophosphine-boranes (R₂ NPH₂ ?BH₃ ) that are convenient building blocks but without the protecting BH₃ moiety thermally labile and notoriously difficult to handle. The borane-protected primary phosphines can be doubly deprotonated using n-butyllithium to provide soluble phosphanediides Li₂ [RP?BH₃ ] of which the phenyl-derivative Li₂ [PhP?BH₃ ] was structurally characterized in the solid state.

SUBMITTER: de Jong GB 

PROVIDER: S-EPMC7756754 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature