Ontology highlight
ABSTRACT:
SUBMITTER: Burgess JT
PROVIDER: S-EPMC5260870 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Burgess Joshua T JT Bolderson Emma E Adams Mark N MN Baird Anne-Marie AM Zhang Shu-Dong SD Gately Kathy A KA Umezawa Kazuo K O'Byrne Kenneth J KJ Richard Derek J DJ
Cell death & disease 20161110 11
Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and promote growth and survival. The putative tumour suppressor, SASH1 (SAM and SH3 domain containing protein 1), has been previously implicated in the regulation of apoptosis; however, the molecular role of SASH1 in this process is still unclear. In this study, we demonstrate that ...[more]