Ontology highlight
ABSTRACT:
SUBMITTER: Chen CM
PROVIDER: S-EPMC5278440 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Chen Chih-Ming CM Orefice Lauren L LL Chiu Shu-Ling SL LeGates Tara A TA Hattar Samer S Huganir Richard L RL Zhao Haiqing H Xu Baoji B Kuruvilla Rejji R
Proceedings of the National Academy of Sciences of the United States of America 20170109 4
Stability of neuronal connectivity is critical for brain functions, and morphological perturbations are associated with neurodegenerative disorders. However, how neuronal morphology is maintained in the adult brain remains poorly understood. Here, we identify Wnt5a, a member of the Wnt family of secreted morphogens, as an essential factor in maintaining dendritic architecture in the adult hippocampus and for related cognitive functions in mice. Wnt5a expression in hippocampal neurons begins post ...[more]