Ontology highlight
ABSTRACT:
SUBMITTER: Liszczak GP
PROVIDER: S-EPMC5278450 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Liszczak Glen P GP Brown Zachary Z ZZ Kim Samuel H SH Oslund Rob C RC David Yael Y Muir Tom W TW
Proceedings of the National Academy of Sciences of the United States of America 20170109 4
Recent advances in the field of programmable DNA-binding proteins have led to the development of facile methods for genomic localization of genetically encodable entities. Despite the extensive utility of these tools, locus-specific delivery of synthetic molecules remains limited by a lack of adequate technologies. Here we combine the flexibility of chemical synthesis with the specificity of a programmable DNA-binding protein by using protein trans-splicing to ligate synthetic elements to a nucl ...[more]