Unknown

Dataset Information

0

Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors.


ABSTRACT: Natural killer (NK) cell function is regulated by NK cell receptors that bind classical MHC class I molecules or their structural relatives. The latter group includes self-ligands (MICA, RAE-I, H-60), as well as ligands encoded by viruses (UL18, m155, m157). Two distinct families of NK receptors have been identified: the immunoglobulin-like family (KIRs, LIRs) and the C-type lectin-like family (Ly49s, NKG2D, CD94/NKG2). Here we describe the crystal structures of NK receptors that have been determined to date, both in free form and bound to MHC class I or MHC class I-like molecules.

SUBMITTER: Deng L 

PROVIDER: S-EPMC2519613 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors.

Deng Lu L   Mariuzza Roy A RA  

Seminars in immunology 20060601 3


Natural killer (NK) cell function is regulated by NK cell receptors that bind classical MHC class I molecules or their structural relatives. The latter group includes self-ligands (MICA, RAE-I, H-60), as well as ligands encoded by viruses (UL18, m155, m157). Two distinct families of NK receptors have been identified: the immunoglobulin-like family (KIRs, LIRs) and the C-type lectin-like family (Ly49s, NKG2D, CD94/NKG2). Here we describe the crystal structures of NK receptors that have been deter  ...[more]

Similar Datasets

| S-EPMC3100565 | biostudies-literature
| S-EPMC3972465 | biostudies-literature
| S-EPMC2770797 | biostudies-literature
| S-EPMC10192222 | biostudies-literature
| S-EPMC3030123 | biostudies-literature
| S-EPMC6352444 | biostudies-literature
| S-EPMC2787854 | biostudies-literature
| S-EPMC5584936 | biostudies-literature
| S-EPMC1171097 | biostudies-other
| S-EPMC3256878 | biostudies-literature