Ontology highlight
ABSTRACT:
SUBMITTER: Deng L
PROVIDER: S-EPMC2519613 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Seminars in immunology 20060601 3
Natural killer (NK) cell function is regulated by NK cell receptors that bind classical MHC class I molecules or their structural relatives. The latter group includes self-ligands (MICA, RAE-I, H-60), as well as ligands encoded by viruses (UL18, m155, m157). Two distinct families of NK receptors have been identified: the immunoglobulin-like family (KIRs, LIRs) and the C-type lectin-like family (Ly49s, NKG2D, CD94/NKG2). Here we describe the crystal structures of NK receptors that have been deter ...[more]