Ontology highlight
ABSTRACT:
SUBMITTER: Horton W
PROVIDER: S-EPMC5282889 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Horton William W Sood Abha A Peerannawar Swarada S Kugyela Nandor N Kulkarni Aditya A Tulsan Rekha R Tran Chris D CD Soule Jessica J LeVine Harry H Török Béla B Török Marianna M
Bioorganic & medicinal chemistry letters 20161124 2
The design, synthesis and assessment of β-carboline core-based compounds as potential multifunctional agents against several processes that are believed to play a significant role in Alzheimer's disease (AD) pathology, are described. The activity of the compounds was determined in Aβ self-assembly (fibril and oligomer formation) and cholinesterase (AChE, BuChE) activity inhibition, and their antioxidant properties were also assessed. To obtain insight into the mode of action of the compounds, HR ...[more]