Genetic variants in the PIWI-piRNA pathway gene DCP1A predict melanoma disease-specific survival.
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ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC5282969 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Genetic variants in the PIWI-piRNA pathway gene DCP1A predict melanoma disease-specific survival.
Zhang Weikang W Liu Hongliang H Yin Jieyun J Wu Wenting W Zhu Dakai D Amos Christopher I CI Fang Shenying S Lee Jeffrey E JE Li Yi Y Han Jiali J Wei Qingyi Q
International journal of cancer 20160914 12
The Piwi-piRNA pathway is important for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control and thus may be involved in cancer development. In this study, we comprehensively analyzed prognostic roles of 3,116 common SNPs in PIWI-piRNA pathway genes in melanoma disease-specific survival. A published genome-wide association study (GWAS) by The University of Texas M.D. Anderson Cancer Center was used to identify associated SNPs, which were later validated by another ...[more]
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