Ontology highlight
ABSTRACT:
SUBMITTER: Chen K
PROVIDER: S-EPMC7504905 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Chen Ka K Liu Hongliang H Liu Zhensheng Z Bloomer Wendy W Amos Christopher I CI Lee Jeffrey E JE Li Xin X Nan Hongmei H Wei Qingyi Q
Molecular carcinogenesis 20190822 11
Glutamine dependence is a unique metabolic defect seen in cutaneous melanoma (CM), directly influencing the treatment and prognosis. Here, we investigated the associations between 6025 common single-nucleotide polymorphisms (SNPs) in 77 glutamine metabolic pathway genes with CM-specific survival (CMSS) using genotyping datasets from two published genome-wide association studies (GWASs). In the single-locus analysis, 76 SNPs were found to be significantly associated with CMSS (P < .050, false-pos ...[more]