Ontology highlight
ABSTRACT:
SUBMITTER: Ourailidou ME
PROVIDER: S-EPMC5292237 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Ourailidou Maria E ME Lenoci Alessia A Zwergel Clemens C Rotili Dante D Mai Antonello A Dekker Frank J FJ
Bioorganic & medicinal chemistry 20161201 3
The implications of lysine-specific demethylase-1 (LSD1) in tumorigenesis have urged scientists to develop diagnostic tools in order to explore the function of this enzyme. In this work, we present our efforts on the development of tranylcypromine (TCP)-based functionalized probes for activity-based protein profiling (ABPP) of LSD1 activity. Biotinylated forms of selected compounds enabled dose-dependent enzyme labeling of recombinant LSD1. However, treatment with LSD1 inhibitors did not clearly ...[more]